Publications


Please download the following publications from Research Gate http://www.researchgate.net/ . If you cannot do that, please ask me through “Contact us”.

 

IP Properties

Ona, T. and Kosaihira, A. Method of screening substance with anticancerous activity and apparatus therefor. JP2005-17081A (2005); WO 2005/001472 A1 (2005).

Nomura, M., Matsubara, E., Ona, T. Determination system, selection system, determination method, cell production method, program, and recording medium. JP2009-122016A (2009).

Ona, T. and Kosaihira, A. Monitoring of intercellular mitochondrial polarization. WO2007/069692 A1 (2007); CN 200680052043.8 (2008); EP 1 961 824 A1 (2008); US 2011/0003321 A1 (2011); JP2014-5514233 B2 (2014).

Ona, T., Method for activating two-dimensional cultured cells similarly to three-dimensional culture or in vivo, and use thereof. WO 2013/039112 A1 (2013).

 

Scientific Papers

Kosaihira, A., Fukumori, T., Sakai, K. and Ona, T. A new combination device comprised of surface plasmon resonance and fluorescence microscopy for a rapid screen of anticancer drugs. SEIKAGAKU, 75:1030 (2003).

Fukumori, T., Kosaihira, A., Sakai, K. and Ona, T. Rapid screening of anticancer compounds by a surface plasmon resonance sensor. SEIKAGAKU, 75:1030 (2003).

Ona, T. and Kosaihira, A. Quantitative prediction of therapeutic potential of cancer drugs including pharmacokinetic interactions for apoptosis in 5 min. EJC Suppl, 5:72 (2007).

Shibata, J., Masaki, T. and Ona, T. Quantitative prediction of cancer drug efficacy by AKT and ERK1/2 down regulation in pancreatic cancer. EJC Suppl, 5:82 (2007).

Shibata, J., Masaki, T. and Ona, T. Quantitative prediction of anti-cancer efficacy of polyphenols by AKT and ERK1/2 down regulation. J Clin Biochem Nutr, 41:78 (2007).

Ona, T. and Kosaihira, A. Quantitative screening method and instrumentation of polyphenol for apoptotic efficacy against cancer including pharmacodynamic interactions. J Clin Biochem Nutr, 41: 80 (2007).

Kosaihira, A. and Ona, T. Rapid and quantitative method for evaluating the personal therapeutic potential of cancer drugs. Anal Bioanal Chem, 391:1889 (2008).

Ona, T., Nishijima, H., Kosaihira, A. and Shibata, J. Development of cell-based quantitative evaluation method for cell cycle-arrest type cancer drugs for apoptosis by high precision surface plasmon resonance sensor. Biophotonics 9:69910R (2008).

Nishijima, H., Kosaihira, A., Shibata, J. and Ona, T. Development of signaling echo method for cell-based quantitative efficacy evaluation of anti-cancer drugs in apoptosis without drug presence using high-precision surface plasmon resonance sensing. Anal Sci, 26:529 (2010).

Ona, T. and Shibata, J. Advanced dynamic monitoring of cellular status using label-free and non-invasive cell-based sensing technology for the prediction of anti-cancer drug efficacy. Anal Bioanal Chem, 398:2505 (2010).

Ona, T. and Shibata, J. Label-free, rapid and reliable new chemosensitivity test for physiological concentration of anti-cancer drug: evaluation within 1h. J Pharm Sci, 121:132 (2013).

Ona, T. and Shibata, J. Label-free, rapid and reliable new cell-based assay for physiological concentration of anti-cancer and anti-metabolic syndrome compounds: evaluation within 1h. J Pharm Sci, 121:159 (2013).

Ona, T. and Shibata, J. Rapid and quantitative efficacy prediction of bioactive compound for skin turnover with toxicity at physiological concentration – Evaluation within 1 h -. AATEX, 18:226 (2013).

Ona, T. and Shibata, J. Cell-based rapid and quantitative toxicity and efficacy monitoring in consecutive before and after the compound metabolism within liver for two ginger compounds at physiological concentration. ALTEX Proc, 3:24 (2014).

Ona, T. and Shibata, J. Rapid in vivo-like efficacy and toxicity evaluation of target compound using mitochondria activity change within epidermis keratinocyte cell. FRAGRANCE J, 42:50 (2014).

Ona, T. and Shibata, J. A plan for development of universal method in skin stimulus measurement using epidermal keratinocyte mitochondria as a forefront of sensory system for homeostasis maintenance. AATEX, 19:162 (2014).

Ona, T., Shibata, J., Hayakawa, A. and Sakamoto, S. Rapid in vivo-like cell-based assay of epidermis pro-turnover efficacy with toxicity by homogenized Kiwi fruits. AATEX, 19:174 (2014).

 

Books

Kosaihira, A., Fukumori, T., Sakai, K. and Ona, T. Rapid screen of antiproliferative phenolic compounds with simultaneous analysis of cancer cell reaction by a new combination device of surface plasmon resonance and fluorescence microscopy. 10th European Conference on the Spectroscopy of Biological Molecules, Eds. Balázs, S. and Zoltán, K.,Biological Molecules, Balázs, S. and Zoltán, K., 71, JATEPress (2003).

Kosaihira, A., Fukumori, T., Sakai, K. and Ona, T. A new combination device comprised of surface plasmon resonance and fluorescence microscopy for a rapid screening of anticancer phenolic compounds. Improvement of forest resources for recyclable forest products, Ed. Ona, T., 170, Springer-Verlag (2004).

 

Proceedings

Kosaihira, A., Fukumori, T., Sakai, K. and Ona, T. A new combination device comprised of Surface plasmon resonance and fluorescence microscopy for rapid screen of anticancer compounds. Abstracts of the 2nd International Conference on Advanced Vibrational Spectroscopy, Nottingham, UK, 236, Aug 24-29 (2003).

Kosaihira, A., Fukumori, T., Sakai, K. and Ona, T. A new combination device comprised of surface plasmon resonance and fluorescence microscopy for a rapid screening of anticancer phenolic compounds. Abstracts of 4th Symposium on the Improvement of Forest Resources for Recyclable Forest Products, 137, Fukuoka, Japan, Nov 9-11 (2003).

Kosaihira, A., Ona, T., Mizumoto, K. and Tanaka, M. Rapid and non-label method for quantification of therapeutic potential of anticancer drug by surface plasmon resonance in the use of living cancer cells. Colloquium Spectroscopicum Internationale XXXIV, 294, Antwerp, Belgium, Sep 4-9 (2005).

Kosaihira, A., Ona, T., Mizumoto, K. and Tanaka, M. Rapid and non – label cell – based screening method for anticancer drug by surface plasmon resonance. International Chemical Congress of Pacific Basin Societies, 41, Honolulu, Hawaii, USA, Dec 15-20 (2005).

Masaki, T., Ona, T., Mizumoto, K. and Tanaka, M. Mechanism of apoptosis induced by trans-resveratrol in human pancreatic cancer cell line, MIA PaCa-2. International Chemical Congress of Pacific Basin Societies, 307, Honolulu, Hawaii, USA, Dec 15-20(2005).

Kosaihira, A., Mizumoto, K., Tanaka, M. and Ona, T. Identification of molecular mechanism of apoptosis via mitochondrial pathway detected by surface plasmon resonance. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, 444, Kyoto, Japan, Jun 18-23 (2006).

Ona, T., Shibata, J. and Kosaihira, A. Quantitative prediction of therapeutic potential of cancer drugs including pharmacokinetic interactions for apoptosis by monitoring mitochondrial polarity. Cell Polarity, 112, Hayama, Japan, Dec 9, 10 (2007).

Ona, T., Nishijima, H., Kosaihira, A. and A. Shibata, J. Development of cell-based quantitative evaluation method for cell cycle-arrest type cancer drugs for apoptosis by high precision surface plasmon resonance sensor. Photonics Europe 2008, 60, Strasbourg, France, Apr 7-10 (2008).

Shibata, J. and Ona, T. Development of wave-guided surface plasmon spectrometer for cancer drug efficacy evaluation aiming personal therapy. Photonics Europe 2008, 66, Strasbourg, France, Apr 7-10 (2008).

Shibata, J., Kosaihira, A. and Ona, T. Development of cell-based quantitative evaluation method and instrument on personal therapeutic potential of cancer drugs for apoptosis by high precision surface plasmon resonance sensor. Third International Conference “Smart Materials, Structures and Systems”, 105, Acireale, Sicily, Italy, Jun 8-13 (2008).

Ona, T., Nishijima, H., Kosaihira, A. and Shibata, J. Rapid and quantitative method for evaluating the therapeutic potential of liver cancer drugs. World Congress of Pharmacy and Pharmaceutical Sciences 2008, 68th International Congress of FIP, 181, Basel, Switzerland, Aug 29-Sep 4 (2008).

Shibata, J., Kosaihira, A. and Ona, T. Rapid and quantitative method for evaluating the personal therapeutic potential of pancreatic cancer drugs. World Congress of Pharmacy and Pharmaceutical Sciences 2008, 68th International Congress of FIP, 182, Basel, Switzerland, Aug 29-Sep 4 (2008).

Ona, T. New chemosensitivity test for physiological concentration of anti-cancer drug: Rapid and reliable prediction within 1 h. The 71st Annual Meeting of the Japanese Cancer Association, 54, Sapporo, Japan, Sep 19-21 (2012).

Ona, T. and Shibata, J. Activation of skin by AHCC. The 21st International Congress on Nutrition and Integrative Medicine (ICNIM 2013), 76, Sapporo, Japan, Jul 27, 28 (2013).

Shibata, J. and Ona, T. Development of label-free, rapid and reliable efficacy prediction of anti-cancer drug at physiological concentration using high-precision surface plasmon resonance. The Twelfth Asian Conference on Analytical Sciences (ASIANALYSIS XII), 3H3-AM6, Fukuoka, Japan, Aug 22-24 (2013).

Ona, T. and Shibata, J. Activation of skin by AHCC: comparison between whole and low molecular weight fraction. The 22nd International Congress on Nutrition and Integrative Medicine (ICNIM 2014), 33, Sapporo, Japan, Jul 26, 27 (2014).

Shibata, J., Yano, S., Seino, T., and Ona, T. Anti-liver effect of Chinese chive using in vivo-like test. The 22nd International Congress on Nutrition and Integrative Medicine (ICNIM 2014), 49, Sapporo, Japan, Jul 26, 27 (2014).

Ona, T. and Shibata, J. New in vivo-like chemosensitivity test for physiological concentration of anti-cancer drug: Rapid and reliable prediction within 1 h. Drug Discovery 2014, 75, Manchester, UK, Sep 2, 3 (2014).

Shibata, J. and Ona, T. Development of in vivo-like cell-based screening system for rapid and quantitative toxicity and efficacy predictions against epidermis activation. Drug Discovery 2014, 85, Manchester, UK, Sep 2, 3 (2014).

 

Presentations

Kosaihira, A., Fukumori, T., Sakai, K. and Ona, T. A new combination device comprised of Surface plasmon resonance and fluorescence microscopy for rapid screen of anticancer compounds. The 2nd International Conference on Advanced Vibrational Spectroscopy, Nottingham, UK, Aug 24-29 (2003).

Kosaihira, A., Mizumoto, K., Tanaka, M. and Ona, T. Identification of molecular mechanism of apoptosis via mitochondrial pathway detected by surface plasmon resonance. 20th IUBMB International Congress of Biochemistry and Molecular Biology and 11th FAOBMB Congress, Kyoto, Japan, Jun 18-23 (2006).

Ona, T. and Kosaihira, A. Quantitative prediction of therapeutic potential of cancer drugs including pharmacokinetic interactions for apoptosis in 5 min. The European Cancer Conference, Barcelona, Spain, Sep23-27 (2007).

Shibata, J., Masaki, T. and Ona, T. Quantitative prediction of cancer drug efficacy by AKT and ERK1/2 down regulation in pancreatic cancer. The European Cancer Conference, Barcelona, Spain, Sep23-27 (2007).

Shibata, J., Masaki, T. and Ona, T. Quantitative prediction of anti-cancer efficacy of polyphenols by AKT and ERK1/2 down regulation. International Conference on Food Factors for Health Promotion ( ICoFF2007), Kyoto, Japan, Nov28-Dec1 (2007).

Ona, T. and Kosaihira, A. Quantitative Screening Method and Instrumentation of polyphenol for apoptotic efficacy against cancer including pharmacodynamic interactions. International Conference on Food Factors for Health Promotion ( ICoFF2007), Kyoto, Japan, Nov28-Dec1 (2007).

Ona, T., Shibata, J. and Kosaihira, A. Quantitative prediction of therapeutic potential of cancer drugs including pharmacokinetic interactions for apoptosis by monitoring mitochondrial polarity. Cell Polarity, Hayama, Japan, Dec9, 10 (2007).

Ona, T., Nishijima, A., Kosaihira, A. and Shibata, J. Development of cell-based quantitative evaluation method for cell cycle-arrest type cancer drugs for apoptosis by high precision surface plasmon resonance sensor. Photonics Europe 2008, Strasbourg, France, Apr7-10 (2008).

Shibata, J. and Ona, T. Development of wave-guided surface plasmon spectrometer for cancer drug efficacy evaluation aiming personal therapy. Photonics Europe 2008, Strasbourg, France, Apr7-10 (2008).

Ona, T., Kosaihira, A. and Shibata, J. Rapid and quantitative method and instrument for evaluating the personal therapeutic potential of cancer drugs. Analytica Conference 2008, Munich、Germany, Apr1-4 (2008).

Shibata, J., Kosaihira, A. and Ona, T. Development of cell-based quantitative evaluation method and instrument on personal therapeutic potential of cancer drugs for apoptosis by high precision surface plasmon resonance sensor. Third International Conference “Smart Materials, Structures and Systems”, Acireale, Sicily, Italy, Jun8-13 (2008).

Ona, T., Nishijima, H., Kosaihira, A. and Shibata, J. Rapid and quantitative method for evaluating the therapeutic potential of liver cancer drugs. World Congress of Pharmacy and Pharmaceutical Sciences 2008, 68th International Congress of FIP, Basel, Switzerland, Aug29-Sep4 (2008).

Shibata, J., Kosaihira, A. and Ona, T. Rapid and quantitative method for evaluating the personal therapeutic potential of pancreatic cancer drugs. World Congress of Pharmacy and Pharmaceutical Sciences 2008, 68th International Congress of FIP, Basel, Switzerland, Aug29-Sep4 (2008).

Ona, T. and Shibata, J. Rapid and reliable cell-based sensing technology for efficacy prediction of anti-cancer and anti-metabolic syndrome compounds. 2012 Bio International Convention, Boston, USA, Jun18-21 (2012).

Ona, T. and Shibata, J. Activation of skin by AHCC. The 21st International Congress on Nutrition and Integrative Medicine (ICNIM 2013), Sapporo, Japan, Jul27, 28 (2013).

Shibata, J. and Ona, T. Development of label-free, rapid and reliable efficacy prediction of anti-cancer drug at physiological concentration using high-precision surface plasmon resonance. The Twelfth Asian Conference on Analytical Sciences (ASIANALYSIS XII), Fukuoka, Aug22-24 (2013).

Ona, T. and Shibata, J. Activation of skin by AHCC: comparison between whole and low molecular weight fraction. The 22nd International Congress on Nutrition and Integrative Medicine (ICNIM 2014), Sapporo, Jul26, 27 (2014).

Shibata, J., Yano, S., Seino, T., and Ona, T. Anti-liver effect of Chinese chive using in vivo-like test. The 22nd International Congress on Nutrition and Integrative Medicine (ICNIM 2014), Sapporo, Jul26, 27 (2014).

Ona, T. and Shibata, J. Cell-based rapid and quantitative toxicity and efficacy monitoring in consecutive before and after the compound metabolism within liver for two ginger compounds at physiological concentration. 9th World Congress on Alternatives and Animal Use in the Life Sciences, Prague, Czech, Aug24-28 (2014).

Ona, T. and Shibata, J. New in vivo-like chemosensitivity test for physiological concentration of anti-cancer drug: Rapid and reliable prediction within 1 h. Drug Discovery 2014, Manchester, UK, Sep2, 3 (2014).

Ona, T. and Shibata, J. Development of in vivo-like cell-based screening system for rapid and quantitative toxicity and efficacy predictions against epidermis activation. Drug Discovery, Manchester, UK, Sep2, 3 (2014).

 

Awards

Hot Article Award, Analytical Sciences, The Japan Society for Analytical Chemistry, 2010.

Best Poster (presentation) Award, The 26th Annual Meeting of Japanese Society for Alternatives to Animal Experiments, The Japan Society for Alternatives to Animal Experiments, 2013.

Lush Prize 2014 Science Award, Finalist, Lush Prize Organization, 2014.